Primary outcome measures are presence of PPCS and quality of life, as measured by the Post-Concussion Symptom Scale and the Quality of Life after Brain Injury questionnaires, respectively. Follow-up is conducted via telephone interview at 1, 3, 6 and 12 months after injury. In Phase II, participants undergo neuropsychological evaluation, exercise tolerance and vestibular/ocular motor screening, MRI, quantitative electroencephalography and blood-based biomarker assessment. Phase I collates data on demographics, medical background, lifestyle habits, nature of injury and acute mTBI symptomatology. CREST will create a state-wide research dataset of mTBI cases, with data being collected in two phases. CREST is recruiting adults aged 18–65 from medical and community-based settings with acute diagnosis of mTBI. Methods and analysis The Concussion Recovery Study ( CREST) is a prospective, longitudinal observational cohort study conducted in Perth, Western Australia. Correspondence to Professor Melinda Fitzgerald.30 Emergency Medicine, Royal Perth Hospital, The University of Western Australia, Perth, Western Australia, Australia.29 The Neurological Intervention & Imaging Service of Western Australia at Sir Charles Gairdner Hospital, Nedlands, Western Australia, Australia.28 Division of Surgery, School of Medicine, The University of Western Australia, Crawley, Western Australia, Australia.27 Telethon Kids Institute, West Perth, Western Australia, Australia.26 Head of Department, Sir Charles Gairdner Hospital, Royal Perth Hospital and Fiona Stanley Hospital, Perth, Western Australia, Australia.25 Statewide Director of Neurosurgery, Department of Health Government of Western Australia, Perth, Western Australia, Australia.24 The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, China.23 Emergency Department, Armadale Health Service, Mount Nasura, Western Australia, Australia.22 Division of Emergency Medicine, School of Medicine, The University of Western Australia, Crawley, Western Australia, Australia.21 Emergency Department, Sir Charles Gairdner Hospital, Nedlands, Western Australia, Australia.20 Royal Flying Doctor Service- Western Operations, Jandakot, Western Australia, Australia.19 Emergency Department, Royal Perth Hospital, Perth, Western Australia, Australia.18 Emergency Department, Saint John of God Hospital Murdoch, Murdoch, Western Australia, Australia.
17 Curtin Medical School, Curtin University, Bentley, Western Australia, Australia.16 School of Medicine, The University of Notre Dame and Curtin Medical School, Curtin University, Perth, Western Australia, Australia.15 Emergency Department, Saint John of God Midland Public Hospital, Midland, Western Australia, Australia.14 Emergency Department, Joondalup Health Campus, Joondalup, Western Australia, Australia.13 Emergency Department, Rockingham General Hospital, Cooloongup, Western Australia, Australia.12 Centre for Clinical Research in Emergency Medicine, Harry Perkins Institute of Medical Research, Nedlands, Western Australia, Australia.11 Emergency Department, Fiona Stanley Hospital, Murdoch, Western Australia, Australia.10 School of Physiotherapy and Exercise Science, Curtin University Faculty of Health Sciences, Bentley, Western Australia, Australia.9 Institute for Immunology and Infectious Diseases, Murdoch University, Murdoch, Western Australia, Australia.8 School of Human Sciences, The University of Western Australia, Crawley, Western Australia, Australia.7 The Centre for Healthy Ageing, Health Futures Institute, Murdoch University, Murdoch, Western Australia, Australia.6 Australian Alzheimer's Research Foundation, Nedlands, Western Australia, Australia.5 School of Psychological Science, The University of Western Australia, Crawley, Western Australia, Australia.4 Division of Surgery, Faculty of Health & Medical Sciences, The University of Western Australia, Crawley, Western Australia, Australia.3 Centre for Clinical Research Excellence, School of Population Health, Curtin University, Bentley, Western Australia, Australia.2 Perron Institute of Neurological and Translational Science, Nedlands, Western Australia, Australia.1 Curtin Health Innovation Research Institute, Curtin University Faculty of Health Sciences, Bentley, Western Australia, Australia.
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